ABHD2

Alternative Name: Abhydrolase Domain Containing 2, 2-Arachidonoylglycerol Hydrolase, Monoacylglycerol Lipase ABHD2, Lung Alpha/Beta Hydrolase 2, Protein PHPS1-2, LABH2, Alpha/Beta Hydrolase Domain Containing Protein 2

Description: ABHD2 is an acylglycerol lipase enzyme that catalyzes endo-cannabinoids 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) only in the presence of progesterone (P4). AGs have been shown to act as inhibitors of CatSper, a sperm-specific calcium channel. Upon P4 stimulation, ABHD2 leads to the activation of CatSper, which results in sperm activation.

Target

Product Details

Hormonal: No

Role in reproduction: Sperm Function

Multipurpose Preventive Technology (MPT): No

Status Details

Project Phase: Discovery and Early Development

Development Stage: Target Validation

Additional Information

References:
  • Miller MR, et al. (2016). Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. Science. 352(6285):555-559.
     

  • Miyata K, et al. (2005). Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the α/β hydrolase domain containing 2 gene. Biochemical and Biophysical Research Communication. 329(1):296-304.

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