ADCY10 and cAMP

Alternative Name: Adenylate Cyclase 10 and cyclic adenosine monophopshate, sAC and cAMP, soluble adenylyl cyclase

Description: ADCY10 belongs to the class of adenylyl cyclases (ACs), enzymes responsible for intracellular cAMP production. ADCY10-null male mice are infertile, with normal spermatogenesis but impaired motility. Sperm show flagellar angularity, an irreversibly altered protein tyrosine phosprophorylation pattern, and an inability to fertilize eggs in vitro. Stimulation of this enzyme is regulated by bicarbonate.

Target

Product Details

User: Female, Male

Hormonal: No

Role in reproduction: Spermatogenesis, Sperm Maturation, Sperm Function

Multipurpose Preventive Technology (MPT): No

Status Details

Project Phase: Discovery and Early Development

Development Stage: Target Validation

Additional Information

References:
  • Buffone, M.G., Wertheimer, E.V., Visconti, P.E., Krapf, D. (2014). Central role of soluble adenylyl cyclase and cAMP in sperm physiology. Biochimica et Biophysica Acta, 1842, 2610–2620.

  • Esposito, G., Jaiswal, B., Xie, F., Krajnc-Franken, M., Robben, T., Strik, A., Kuil, C., Philipsen, R., van Duin, M., Conti,M. and Gossen, J. (2004). Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proceedings of the National Academy of Sciences, 101(9), pp.2993-2998.

  • Hess, K. C., Jones, B. H., Marquez, B., Chen, Y., Ord, T. S., Kamenetsky, M., . . . Moss, S. B. (2005). The “Soluble” Adenylyl Cyclase in Sperm Mediates Multiple Signaling Events Required for Fertilization.Developmental Cell,9(2), 249-259.

  • Kleinboelting,S., Diaz, A., Moniot, S., Heuvel, J. V., Weyand, M., Levin, L. R., . . . Steegborn, C. (2014). Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.Proceedings of the National Academy of Sciences,111(10), 3727-3732.

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