Alternative Name: Androglobin, Calpain-7-Like Protein, C6orf103, Chromosome 6 Open Reading Frame 103, CAPN16, CAPN7L

Description: Androglobin is a novel type of globin whose function in reproduction remains to be determined. Androglobins are speculated to bind oxygen and play a role in both sensing oxygen and detoxifying reactive oxygen species in sperm. In humans and mice, androglobin is predominantly expressed in testis tissue and has demonstrated insensitivity to hypoxia. Preliminary evidence exists for increased expression of ADGB in fertile compared to infertile males.

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  • Hoogewijs D, Ebner B, Germani F, Hoffmann FG, Fabrizius A, Moens L, Burmester T, Dewilde S, Storz JF, Vinogradov SN, Hankeln T. Androglobin: a chimeric globin in metazoans that is preferentially expressed in Mammalian testes. Mol Biol Evol. 2012 Apr;29(4):1105-14. doi: 10.1093/molbev/msr246. PMID: 22115833.

  • Santambrogio S, Bracke A, Bicker A, Dewilde S, Hankeln T, Wengerm R, Hoogewijs D. Androglobin, the fifth mammalian oxygen-binding globin contributes to male fertility (P023 Poster Abstract). Acta Physiol (Oxf). 2015 Mar;213 Suppl 699:4-199. doi: 10.1111/apha.12479.

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