ALDH1a2 Inhibitors
Alternative Name: Inhibitors of Testicular Retinoic Acid Biosynthesis
Description: ALDH1A2 is an enzyme involved in testicular retinoic acid biosynthesis, that if blocked can arrest spermotogenesis. Small molecule inhibitors of ALDH1A2 are being developed as long-term oral, reversible male contraceptives, based on earlier work on bisdichloroacetyldiamines (BDADs).
Product Details
User: Male
Hormonal: No
Delivery Method: Oral
Duration Type: Long-acting
Duration: Months to years
Regimen: - daily
- daily
Active Pharmaceutical Ingredient (API): - ALDH1A2 inhibitors
- ALDH1A2 inhibitors
Multipurpose Preventive Technology (MPT): No
Status Details
Developer: University of Washington, University of Minnesota
Project Phase: Pre-Clinical and Clinical Development
Development Stage: Pre-clinical
Active Development: Yes
Status Details: - Currently conducting preclinical, in vitro, and early-phase animal testing.
- Study on ALDH1a2 mechanism of action published in 2018.
- Currently conducting preclinical, in vitro, and early-phase animal testing.
- Study on ALDH1a2 mechanism of action published in 2018.
Additional Information
References: Paik J, et al. (2014) Inhibition of Retinoic Acid Biosynthesis by the Bisdichloroacetyldiamine WIN 18,446 Markedly Suppresses Spermatogenesis and Alters Retinoid Metabolism in Mice. The Journal of Biological Chemistry. 289(21):15104-15117.
Chen Y, et al. (2018). Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors. ACS Chem Biol. 13(3):582-590.
Paik J, et al. (2014) Inhibition of Retinoic Acid Biosynthesis by the Bisdichloroacetyldiamine WIN 18,446 Markedly Suppresses Spermatogenesis and Alters Retinoid Metabolism in Mice. The Journal of Biological Chemistry. 289(21):15104-15117.
Chen Y, et al. (2018). Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors. ACS Chem Biol. 13(3):582-590.
Footnotes: - See entry on Bisdichloroacetyldiamines (BDADs).
- See entry on Bisdichloroacetyldiamines (BDADs).