ALDH1a2 Inhibitors

Product Overview

Alternative Name: Inhibitors of Testicular Retinoic Acid Biosynthesis

Development Status: Active Development

Target: Male

Mode: Non-hormonal

Delivery Type: Oral

Duration Type: Long-acting

Description: ALDH1A2 is an enzyme involved in testicular retinoic acid biosynthesis, that if blocked can arrest spermotogenesis. Small molecule inhibitors of ALDH1A2 are being developed as long-term oral, reversible male contraceptives, based on earlier work on bisdichloroacetyldiamines (BDADs).

Updated date: March 06, 2017

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Status

Project Phase: Early Development

Project Stage: Pre-clinical

Status Details:
  • Currently conducting preclinical, in vitro, and early-phase animal testing.

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