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Bisdichloroacetyldiamines (BDADs, e.g. WIN 18,446) were shown to inhibit testicular retinoic acid biosynthesis and complete arrest of spermatogenesis.
July 18, 2016
Active Pharmaceutical Ingredient (API):
Potential Multi-Purpose Technology (MPT):
University of Washington
Began discovery in:
Known to cause unpleasant disulfirim reactions when administered with alcohol due to inhibition of ALDH2 (involved in alcohol metabolism in liver), so further development was abandoned.
Effective in limited human trials with no evidence of significant side effects. No obvious effects on serum testosterone or sexual function.
Known to cause unpleasant disulfirim reactions when administered with alcohol.
See also ALDH1A2 Inhibitors.
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