Carica Papaya Extract | The Contraceptive Pipeline Database

Product Overview

Development Status: Active Development

Target: Male

Mode: Non-hormonal

Delivery Type: Oral

Duration Type: Short-acting

Description: Chloroform extract of Carica papaya seeds; 50 mg/kg body weight/day orally.

Updated date: May 30, 2018

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Product Details

Active Pharmaceutical Ingredient (API): Chloroform extract of Carica papaya seeds

Potential Multi-Purpose Technology (MPT): No

Regimen: daily

Duration: one day

Dose: 50 mg/kg body weight

Partner: University of Rajasthan, India

Status

Project Phase: Early Development

Project Stage: Phase I

Status Details:
Effectiveness has been proven in monkey and murine models. Active compound being isolated; manufacturing feasibility depends on this step, as uniform, reproducible, large-scale manufacturing directly from plant compounds is extremely difficult.

Programmatic Considerations

Considerations:
Chloroform extract shows no toxicity at 10 times the contraceptive dose; tests performed include developmental toxicity and teratogenetic potential as well as acute, chronic, subchronic, subchronic and carcinogenicity.

Several month lag in achieving contraceptive level of sperm suppression. Sperm count required to confirm onset of efficacy.

Used in India as a traditional medicine.

Additional Information

Additional Information:
Lohiya, N.K., B. Manivannan, et al. (2008). Sperm motility inhibitory effect of the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in langur monkey. Asian J Androl 10(2):298-306

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