Carica Papaya Extract | The Contraceptive Pipeline Database

Product Overview

Description: Chloroform extract of Carica papaya seeds; 50 mg/kg body weight/day orally.

Updated date: May 30, 2018

Vertical Tabs

Product Details

Duration: one day

Dose: 50 mg/kg body weight

Status

Status Details:
Effectiveness has been proven in monkey and murine models. Active compound being isolated; manufacturing feasibility depends on this step, as uniform, reproducible, large-scale manufacturing directly from plant compounds is extremely difficult.

Programmatic Considerations

Considerations:
Chloroform extract shows no toxicity at 10 times the contraceptive dose; tests performed include developmental toxicity and teratogenetic potential as well as acute, chronic, subchronic, subchronic and carcinogenicity.

Several month lag in achieving contraceptive level of sperm suppression. Sperm count required to confirm onset of efficacy.

Used in India as a traditional medicine.

Additional Information

Additional Information:
Lohiya, N.K., B. Manivannan, et al. (2008). Sperm motility inhibitory effect of the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in langur monkey. Asian J Androl 10(2):298-306

Download Product Report