Cinchonine Derivatives

Description: Cinchonine is a natural compound present in Cinchona bark. Synthesis of cinchonine derivatives came about as an effort towards identifying non-detergent spermicides acting through interaction with sulfhydryl groups present on sperm cells.

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  • Pandey, R. R., Srivastava, A., Malasoni, R., Naqvi, A., Jain, A., Maikhuri, J. P., . . . Dwivedi, A. K. (2012). Synthesis of 3-(1-alkyl/aminoalkyl-3-vinyl-piperidin-4-yl)-1-(quinolin-4-yl)-propan-1-ones and their 2-methylene derivatives as potential spermicidal and microbicidal agents.Bioorganic & Medicinal Chemistry Letters,22(17), 5735-5738.

  • Jin, Z., Yan, W., Qu, M., Ge, C., Chen, X., & Zhang, S. (2018). Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells.Experimental and Therapeutic Medicine. doi:10.3892/etm.2018.6005

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