Clean Sheets Pill

Alternative Name: Inhibition of Vas Propulsive Contractility

Description: The coordinated contractions of longitudinal and circular muscles in vas deferens provide the propulsion that sustains transport of spermatic fluid and ensures emission. The Instant Male Pill suppresses this propulsive function by inactivating contractility of longitudinal muscle in vas deferens but not circular muscle contraction. This leads to closure of vas deferens lumen and inhibition of emission, crucially without affecting ejaculatory activity and coincident sensation of orgasm.

Product Details

User: Male

Hormonal: No

Delivery Method: Oral

Duration Type: Short-acting

Duration: Reversible within 24-30 hr

Regimen:
  • When fully developed, it will be taken 1-2 hr before intercourse as needed

Multipurpose Preventive Technology (MPT): Yes

Status Details

Developer: King's College, London

Project Phase: Discovery and Early Development

Development Stage: Lead Optimization

Active Development: Yes

Status Details:
  • Prototypes have been tested successfully in a proof of concept study using rams as an animal model.
  • The project is looking for spin out collaboration and/or funding.

Additional Information

References:
  • Amobi N, et al. (2011) Evaluation of novel, non-hormonal male contraceptive drug prototypes acting in vas deferens.

  • Amobi NI, Smith IC. (1995) Differential inhibition in the human vas deferens by phenoxybenzamine: a possible mechanism for its contraceptive action. J Reprod Fetil. 103(2):215-21.

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