Dermaseptin S4 Derivatives

Alternative Name: K4K20S4

Description: Dermaseptins are a group of peptides derived from the skin of the Phyllomedusa sauvagei from. These compounds display antimicrobial and spermicidal activity. While the exact mechanism of spermicide has not been discovered, S4 contains positive charges, resulting in attraction to phosphatidylglycerol in the sperm plasma membrane.

Product Details

User: Female

Hormonal: No

Delivery Method: Vaginal, Other, Other

Duration Type: Pericoital

Active Pharmaceutical Ingredient (API):
  • K4K20S4 and derivatives

Multipurpose Preventive Technology (MPT): Yes

Status Details

Project Phase: Discovery and Early Development

Development Stage: Lead Optimization

Active Development: Unknown

Additional Information

  • Huang, L., Chen, D., Wang, L., Lin, C., Ma, C., Xi, X., Chen, T., Shaw, C. and Zhou, M. (2017). Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis.Molecules, 22(10), p.1805.

  • Zaïri, A., Tangy, F., & Hani, K. (2013). Dermaseptin S4derivative K4K20S4: A potential candidate for development of a new microbicide contraceptive agent –an in vitro study.The European Journal of Contraception & Reproductive Health Care,18(2), 79-87.

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