Dermaseptin S4 Derivatives
Alternative Name: K4K20S4
Description: Dermaseptins are a group of peptides derived from the skin of the Phyllomedusa sauvagei from. These compounds display antimicrobial and spermicidal activity. While the exact mechanism of spermicide has not been discovered, S4 contains positive charges, resulting in attraction to phosphatidylglycerol in the sperm plasma membrane.
Product Details
User: Female
Hormonal: No
Delivery Method: Vaginal, Other, Other
Duration Type: Pericoital
Active Pharmaceutical Ingredient (API): - K4K20S4 and derivatives
- K4K20S4 and derivatives
Multipurpose Preventive Technology (MPT): Yes
Status Details
Project Phase: Discovery and Early Development
Development Stage: Lead Optimization
Active Development: Unknown
Additional Information
References: Huang, L., Chen, D., Wang, L., Lin, C., Ma, C., Xi, X., Chen, T., Shaw, C. and Zhou, M. (2017). Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis.Molecules, 22(10), p.1805.
Zaïri, A., Tangy, F., & Hani, K. (2013). Dermaseptin S4derivative K4K20S4: A potential candidate for development of a new microbicide contraceptive agent –an in vitro study.The European Journal of Contraception & Reproductive Health Care,18(2), 79-87.
Huang, L., Chen, D., Wang, L., Lin, C., Ma, C., Xi, X., Chen, T., Shaw, C. and Zhou, M. (2017). Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis.Molecules, 22(10), p.1805.
Zaïri, A., Tangy, F., & Hani, K. (2013). Dermaseptin S4derivative K4K20S4: A potential candidate for development of a new microbicide contraceptive agent –an in vitro study.The European Journal of Contraception & Reproductive Health Care,18(2), 79-87.