DMPA + Testosterone

Alternative Name: Depot Medroxyprogesterone Acetate (DMPA) + Testosterone

Description: This combined progestin/androgen method for male contraception used testosterone (four 200-mg implants, every 4 months) and DMPA (300 mg every 3 months).

Product Details

User: Male

Hormonal: Yes

Delivery Method: Injectable, Subdermal

Duration Type: Short-acting

Duration: 3 - 5 months

  • Testosterone every 4 months, DMPA every 3 months

Dose: four 200-mg pellets of testosterone and 300-mg DMPA

Active Pharmaceutical Ingredient (API):
  • medroxyprogesterone acetate
  • testosterone

Multipurpose Preventive Technology (MPT): No

Status Details

Developer: ANZAC Research Institute

Project Phase: Pre-Clinical and Clinical Development

Development Stage: Phase I

Active Development: No

Status Details:
  • 55 healthy men in stable fertile relationships participated in a proof of principle study, with a 12-month contraceptive efficacy period. Sperm density fell rapidly, so 94% of men entered the efficacy phase by 3 months, with only 2 of 55 (3.6%) men not sufficiently suppressed to enter efficacy. No pregnancies occurred in 35.5 person-years. Recovery was complete with medians of 3.6 months to sperm reappearance and 5 months to 20 million sperm/ml.

Additional Information


Vertical Tabs