DMPA + Testosterone
Alternative Name: Depot Medroxyprogesterone Acetate (DMPA) + Testosterone
Description: This combined progestin/androgen method for male contraception used testosterone (four 200-mg implants, every 4 months) and DMPA (300 mg every 3 months).
Product Details
User: Male
Hormonal: Yes
Delivery Method: Injectable, Subdermal
Duration Type: Short-acting
Duration: 3 - 5 months
Regimen: - Testosterone every 4 months, DMPA every 3 months
- Testosterone every 4 months, DMPA every 3 months
Dose: four 200-mg pellets of testosterone and 300-mg DMPA
Active Pharmaceutical Ingredient (API): - medroxyprogesterone acetate
- testosterone
- medroxyprogesterone acetate
- testosterone
Multipurpose Preventive Technology (MPT): No
Status Details
Developer: ANZAC Research Institute
Project Phase: Pre-Clinical and Clinical Development
Development Stage: Phase I
Active Development: No
Status Details: - 55 healthy men in stable fertile relationships participated in a proof of principle study, with a 12-month contraceptive efficacy period. Sperm density fell rapidly, so 94% of men entered the efficacy phase by 3 months, with only 2 of 55 (3.6%) men not sufficiently suppressed to enter efficacy. No pregnancies occurred in 35.5 person-years. Recovery was complete with medians of 3.6 months to sperm reappearance and 5 months to 20 million sperm/ml.
- 55 healthy men in stable fertile relationships participated in a proof of principle study, with a 12-month contraceptive efficacy period. Sperm density fell rapidly, so 94% of men entered the efficacy phase by 3 months, with only 2 of 55 (3.6%) men not sufficiently suppressed to enter efficacy. No pregnancies occurred in 35.5 person-years. Recovery was complete with medians of 3.6 months to sperm reappearance and 5 months to 20 million sperm/ml.
Additional Information
References: ANZAC Research Institute website: http://www.anzac.edu.au/research/andrology/projects/
Turner L, et al. (2003) Contraceptive Efficacy of a Depot Progestin and Androgen Combination in Men. The Journal of Clinical Endocrinology & Metabolism. 88(10);4659-67
ANZAC Research Institute website: http://www.anzac.edu.au/research/andrology/projects/
Turner L, et al. (2003) Contraceptive Efficacy of a Depot Progestin and Androgen Combination in Men. The Journal of Clinical Endocrinology & Metabolism. 88(10);4659-67