DMPA + Testosterone

Product Overview

Alternative Name: Depot Medroxyprogesterone Acetate (DMPA) + Testosterone

Development Status: Inactive

Target: Male

Mode: Hormonal

Delivery Type: Injectable, Subdermal

Duration Type: Long-acting

Description: This combined progestin/androgen method for male contraception used testosterone (four 200-mg implants, every 4 months) and DMPA (300 mg every 3 months).

Updated date: May 30, 2018

Vertical Tabs


Project Phase: Early Development

Project Stage: Phase I

Status Details:
  • 55 healthy men in stable fertile relationships participated in a proof of principle study, with a 12-month contraceptive efficacy period. Sperm density fell rapidly, so 94% of men entered the efficacy phase by 3 months, with only 2 of 55 (3.6%) men not sufficiently suppressed to enter efficacy. No pregnancies occurred in 35.5 person-years. Recovery was complete with medians of 3.6 months to sperm reappearance and 5 months to 20 million sperm/ml.

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