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The Contraceptive Pipeline Database
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Estetrol (E4) + Progestin Combined Pill
20mg E4 plus a progestin in an oral contraceptive.
July 19, 2016
Active Pharmaceutical Ingredient (API):
Potential Multi-Purpose Technology (MPT):
20 mg E4, TBD progestin
Began discovery in:
In 2012, the clinical phase II development of Estelle was completed.
E4 is produced by human fetal liver. As a natural steroid, E4 is expected to be less thrombogenic than synthetic estrogens.
E4 may protect against osteoporosis and breast cancer.
Pantarhei BioScience Fact Sheet:
Estretol in Oral Contraception
Pantarhei Bioscience is no longer involved in development.
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