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Single dose method of non-surgical male sterilization, administered by injection, which has an effect on murine spermatogenesis. Effect is not permanent, so no further development was pursued.
May 30, 2018
Active Pharmaceutical Ingredient (API):
Potential Multi-Purpose Technology (MPT):
Intended to be permanent, but was reversible on testing
University of Washington
Was intended to be a method of permanent sterilization, but effect was not permanent, so no further development was pursued.
Use of FSHβ as a targeting vector to the testes may permit use of lower dose of melphalan and so reduce potential side effects.
Low-cost technology using available compounds, likely to be inexpensive.
Potential for testicular toxicity such as hypogonadism and/or late testicular neoplasms from the melphalan.
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