Alternative Name: Sperm glycolytic enzyme

Description: Glyceraldehyde 3-phosphate dehydrogenase-S (GAPDHS) is a sperm specific enzyme, and is part of the metabolic pathway required to convert glucose into ATP (source of energy for sperm). By binding GAPDHS and inhibiting glycolysis, sperm motility is impaired, thus leading to infertility.

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  • Target has been validated in knock-out mice models. GAPDHS-/- males were infertile and had profound defects in sperm motility
  • ATP levels were 10.4% compared to untreated mice. GAPDHS crystal structure has been mapped and suggests selective inhibition may be possible.
  • High throughput screening is being completed to identify potential lead compounds.

Additional Information

  • Miki K, Qu W, et al. (2004) Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility. Proc Natl Acad Sci USA. 101:16501-16506.

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