GnRH II receptor anatagonists

Product Overview

Alternative Name: Gonadotropin releasing hormone (GnRH) II receptor anatagonists

Target: Female

Mode: Non-hormonal

Delivery Type: TBD

Duration Type: TBD

Description: Unique isoforms of GnRH have been found to have activity in reproductive tissue (GnRH I, II, and III). GnRH AIIA, an GnRH II analog, has been developed. It is proposed that the contraceptive action of GnRH AIIA is through down-regulation of the GnRH II receptor. Further work is required to understand the full complexity of the antagonists action.

Updated date: May 30, 2018

Vertical Tabs

Status

Project Phase: Discovery

Project Stage: Target ID/Validation

Status Details:
  • Contraceptive efficacy has been shown in various animal models including monkey and dog models.
  • Various in vitro and in vivo assays have been developed to test antagonist function and response.
  • Acyline, a third generation GnRH antagonist, has been developed which provides greater metabolic stability and less allergic side-effects.

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