GnRH II receptor anatagonists

Product Overview

Alternative Name: Gonadotropin releasing hormone (GnRH) II receptor anatagonists

Description: Unique isoforms of GnRH have been found to have activity in reproductive tissue (GnRH I, II, and III). GnRH AIIA, an GnRH II analog, has been developed. It is proposed that the contraceptive action of GnRH AIIA is through down-regulation of the GnRH II receptor. Further work is required to understand the full complexity of the antagonists action.

Updated date: May 30, 2018

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Status Details:
  • Contraceptive efficacy has been shown in various animal models including monkey and dog models.
  • Various in vitro and in vivo assays have been developed to test antagonist function and response.
  • Acyline, a third generation GnRH antagonist, has been developed which provides greater metabolic stability and less allergic side-effects.

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