LDH-C

Product Overview

Alternative Name: LDH-C4, Lactate dehydrogenase C

Development Status: Active Development

Target: Male

Mode: Non-hormonal

Delivery Type: Oral

Duration Type: Long-acting

Description: Sperm lacking lactate dehydrogenase C (LDH-C) are non-functional. Evidence suggests that impairment of sperm function involves protein-protein interactions (PPI) between LDH-C and other sperm specific proteins, particularly Ant4 (ATP/ADP translocase). Disruption of the PPI between these two molecules will perturb sperm function and achieve a reversible inhibition of fertility and a level of specificity to obviate potential adverse effects of usage.

Updated date: May 30, 2018

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Status

Project Phase: Discovery

Project Stage: Target ID/Validation

Status Details:
  • The PPI to be targeted is at the stage of validation if and when funding is available to support this approach to developing a male contraceptive.

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