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LDH-C
Product Overview
Alternative Name:
LDH-C4, Lactate dehydrogenase C
Development Status:
Active Development
Target:
Male
Mode:
Non-hormonal
Delivery Type:
Oral
Duration Type:
Long-acting
Description:
Sperm lacking lactate dehydrogenase C (LDH-C) are non-functional. Evidence suggests that impairment of sperm function involves protein-protein interactions (PPI) between LDH-C and other sperm specific proteins, particularly Ant4 (ATP/ADP translocase). Disruption of the PPI between these two molecules will perturb sperm function and achieve a reversible inhibition of fertility and a level of specificity to obviate potential adverse effects of usage.
Updated date:
May 30, 2018
Vertical Tabs
Product Details
Potential Multi-Purpose Technology (MPT):
No
Partner:
Northwestern University
Status
Project Phase:
Discovery
Project Stage:
Target ID/Validation
Status Details:
The PPI to be targeted is at the stage of validation if and when funding is available to support this approach to developing a male contraceptive.
Programmatic Considerations
Additional Information
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