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LDH-C4, Lactate dehydrogenase C
Sperm lacking lactate dehydrogenase C (LDH-C) are non-functional. Evidence suggests that impairment of sperm function involves protein-protein interactions (PPI) between LDH-C and other sperm specific proteins, particularly Ant4 (ATP/ADP translocase). Disruption of the PPI between these two molecules will perturb sperm function and achieve a reversible inhibition of fertility and a level of specificity to obviate potential adverse effects of usage.
May 30, 2018
Potential Multi-Purpose Technology (MPT):
The PPI to be targeted is at the stage of validation if and when funding is available to support this approach to developing a male contraceptive.
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