LDH-C

Alternative Name: LDH-C4, Lactate dehydrogenase C

Description: Sperm lacking lactate dehydrogenase C (LDH-C) are non-functional. Evidence suggests that impairment of sperm function involves protein-protein interactions (PPI) between LDH-C and other sperm specific proteins, particularly Ant4 (ATP/ADP translocase). Disruption of the PPI between these two molecules will perturb sperm function and achieve a reversible inhibition of fertility and a level of specificity to obviate potential adverse effects of usage.

Target

Product Details

User: Male

Hormonal: No

Delivery Method: Oral

Duration Type: Long-acting

Role in reproduction: Sperm Function

Multipurpose Preventive Technology (MPT): No

Status Details

Developer: Northwestern University

Project Phase: Discovery and Early Development

Development Stage: Target Identification

Active Development: Yes

Status Details:
  • The PPI to be targeted is at the stage of validation if and when funding is available to support this approach to developing a male contraceptive.

Additional Information

References:

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