Alternative Name: (3β,13ξ)-Lup-20(29)-en-3-ol; Clerodol; Monogynol B; Fagarasterol; Farganasterol

Description: Lupeol is a triterpenoid, found in several plants, with several types of pharmacological activity. It is proposed that it binds to ABHD2, preventing CatSper activation by progesterone, resulting in contraception.

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Reference target/product: ABHD2

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Additional Information

  • Brenker, C., Schiffer, C., Wagner, I. V., Tüttelmann, F., Röpke, A., Rennhack, A., . . . Strünker, T. (2018). Action of steroids and plant triterpenoids on CatSper Ca2 channels in human sperm.Proceedings of the National Academy of Sciences,115(3).

  • Mannowetz, N., Miller, M. R., & Lishko, P. V. (2017). Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids.Proceedings of the National Academy of Sciences,114(22), 5743-5748.

  • Mannowetz, N., Mundt, N., & Lishko, P. V. (2018). Reply to Brenker et al.: The plant triterpenoid pristimerin inhibits calcium influx into humanspermatozoa via CatSper.Proceedings of the National Academy of Sciences,115(3).

  • Rao, S. D., Rao, B. N., Devi, P. U., & Rao, A. K. (2017). Isolation of Lupeol, Design and Synthesis of Lupeol Derivatives and their Biological Activity.Oriental Journal of Chemistry,33(1), 173-180.

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