Metalloproteinase Inhibitors

Product Overview

Development Status: Active Development

Target: Female

Mode: Non-hormonal

Delivery Type: TBD

Duration Type: TBD

Description: Protease-dependent breakdown of the ovulatory follicle is necessary for its rupture and the ovulation of a fertilizable oocyte. Therefore, inhibiting protease activity would serve as an effective contraceptive by blocking oocyte release and fertilization.

Updated date: July 21, 2016

Vertical Tabs


Project Phase: Discovery

Project Stage: Target ID/Validation

Began discovery in: 2007

Status Details:
  • Studies are underway to determine if select metalloproteinase family members are critical for ovulation so that more selective inhibitors can be developed.
  • A complete and systematic characterization of the primate follicle transciptome led to the identification of all protease encoding genes that are upregulated following an ovulatory stimulus and prior to follicle rupture.
  • Injection of a metalloproteinase inhibtior into the nonhuman primate ovulatory follicle blocked its rupture, without affecting subsequent luteal phase length or steroid production.

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