NES + Testosterone Gel

Alternative Name: Nestorone + Testosterone Gel

Description: Transdermal gel formulation combining nestorone and testosterone in a small volume for daily application.

Product Details

Duration: 48 hours


Dose: NES 8 mg/day + T 62 mg/day

Active Pharmaceutical Ingredient (API):

Inactive material: hydroalcoholic gel

Status Details

Developer: ,

Began discovery in: 2007

Status Details:
  • Dose of combined gel based on previous research with separate gels of each API (i.e., NES and T).
  • Phase 2 study to demonstrate "the efficacy, safety, and acceptability of the gel when used by men in preventing pregnancy among couples in seven countries around the world." ( Identifier: NCT03452111)

Additional Information

  • Population Council website:

  • Roth MY, Shih G, Ilani N, Wang C, Page ST, Bremner WJ, Swerdloff RS, Sitruk-Ware R, Blithe DL, Amory JK. Acceptability of a transdermal gel-based male hormonal contraceptive in a randomized controlled trial. Contraception. 2014 Oct;90(4):407-12. doi: 10.1016/j.contraception.2014.05.013.

  • Ilani N, Roth MY, Amory JK, Swerdloff RS, Dart C, Page ST, Bremner WJ, Sitruk-Ware R, Kumar N, Blithe DL, Wang C. A new combination of testosterone and nestorone transdermal gels for male hormonal contraception. J Clin Endocrinol Metab. 2012 Oct;97(10):3476-86. doi: 10.1210/jc.2012-1384.

  • Identifier: NCT03452111

  • Anawalt BD, Roth MY, Ceponis J, Surampudi V, Amory JK, Swerdloff RS, Liu PY, Dart C, Bremner WJ, Sitruk-Ware R, Kumar N, Blithe DL, Page ST, Wang C. Combined nestorone-testosterone gel suppresses serum gonadotropins to concentrations associated with effective hormonal contraception in men. Andrology. 2019 Nov;7(6):878-887. doi: 10.1111/andr.12603.

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