Ouabain Derivatives

Description: Ouabain, both a plant-derived toxin and endogenous steroid in mammals, inhibits Na,K-ATPase α4 but exhibits toxic effects on the heart. Derivatives have been developed that increase specificity to the α4 isoform.

Product Details

User: Male

Hormonal: Yes

Role in reproduction: Sperm Function

Multipurpose Preventive Technology (MPT): No

Status Details

Developer: University of Kansas Medical Center, University of Minnesota

Project Phase: Discovery and Early Development

Development Stage: Lead Optimization

Active Development: Yes

Additional Information

References:
  • Syeda SS, Sánchez G, et al. (2018) Design, Synthesis, in Vitro and in Vivo Evaluation of Ouabain Analogs as Potent and Selective Na,K-ATPase α4 Isoform Inhibitors for Male Contraception. J Med Chem.

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