Ovaprene

Description: A non-hormonal intravaginal contraceptive ring, which is one-size-fits-all, made from silicone, serves as a barrier, and is designed to continuously release spermiostatic and spermicidal non-drug agents over a four-week period.

Product Details

User: Female

Hormonal: No

Delivery Method: Barrier, Vaginal Ring

Duration Type: Short-acting

Duration: 4 weeks

Regimen:
  • once per month

Inactive material: silicone

Multipurpose Preventive Technology (MPT): Yes

Status Details

Developer: Dare BioScience Inc.

Project Phase: Pre-Clinical and Clinical Development

Development Stage: Phase II

Active Development: Yes

Status Details:
  • Phase II trial was reported completed in 2010. A Phase 1 safety-and-tolerability study concluded that "the Ovaprene device is well-tolerated and acceptable to sexually active women and their partners."
  • Daré began a postcoital clinical trial of Ovaprene® in 2018 (https://clinicaltrials.gov/ct2/show/NCT03598088).

Additional Information

References:
  • Daré Bioscience website: https://www.darebioscience.com/pipeline

  • Del Priore G, et al. (2009) A pilot safety and tolerability study of a nonhormonal vaginal contraceptive ring. J Reprod Med. 54(11-12):685-90.

  • Vaughn MA, et al. (2014) Effects of Ascorbic Acid on Available Ferrous Iron from the Non-Hormonal Contraceptive Ovaprene® Ring. Abstract. Society for Biomaterials.

  • Vaughn MA, et al. (2014) Effects of Ascorbic Acid on Available Ferrous Iron from the Non-Hormonal Contraceptive Ovaprene® Ring. Abstract. Society for Biomaterials.

  • Press Release: http://ir.darebioscience.com/news-releases/news-release-details/dare-bio...

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