PC6 Inhibitor

Product Overview

Alternative Name: Proprotein convertase 6 (PC6) inhibitor

Target: Female, Male

Mode: Non-hormonal

Delivery Type: TBD

Duration Type: TBD

Description: PC6 is a serine protease involved in processing latent precursor proteins into their biologically active products (e.g. growth factors, cell surface receptors, cytokines). Inhibition of PC6 was found to prevent embryo implantation in the mouse uterus. Additionally, PC6 is necessary for viral fusion and therefore HIV infection.

Updated date: May 30, 2018

Vertical Tabs

Status

Project Phase: Discovery

Project Stage: Target ID/Validation

Status Details:
  • Inhibition of PC6 expression at the appropriate time in the uterus was shown to block implantation in mouse models. A known PC6 inhibitor was able to cause some inhibition of implantation in mice, but not near levels required for contraceptive usage. PC6 expression cycles in humans have been established.
  • A lead compound with an acceptable bio-availability and efficacy profile and an acceptable delivery mechanism are needed.

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