Alternative Name: Phosphodiesterase (PDE) 3, 5, 9 inhibitors, PDE3A
Description: Phosphodiesterases (PDE) decrease cyclic AMP and GMP levels, and are important regulators of many biologic systems. There are 11 families. Compartmentalization of PDE isoforms exists, such that type 3A is predominant in the oocyte but not in the somatic cells of the follicle. Selectively blocking PDE3 prevents the final maturation of the oocyte without affecting ovulation or menstrual cyclicity. PDE5 (granulosa cells of the developing follicle) and PDE9 (oocyte) participate indirectly preventing the breakdown of cGMP, an endogeneous regulator of PDE3.
Updated date: May 30, 2018