Peptide LL-37

Product Overview

Development Status: Active Development

Target: Female

Mode: Non-hormonal

Delivery Type: Vaginal Gel, Vaginal Ring

Duration Type: Long-acting, Pericoital

Description: The antimicrobial peptide LL-37, which is in the cathelicidin family, is being tested for its use simultaneously as a contraceptive and an anti-HIV treatment. It will be delivered either as a pericoital vaginal gel in hydroxyethyl cellulose (HEC) or a long-acting vaginal ring.

Updated date: May 30, 2018

Vertical Tabs

Status

Project Phase: Early Development

Project Stage: Lead Optimization

Began discovery in: 2008

Status Details:
  • Preliminary work indicated that 70% of female mice vaginally administered with this LL-37 gel did not become pregnant following natural mating. A higher concentration gel will be tested. The female reproductive tract tissues will be observed for intactness and the presence of recruited immune cells.

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