Peptide LL-37
Description: The antimicrobial peptide LL-37, which is in the cathelicidin family, is being tested for its use simultaneously as a contraceptive and an anti-HIV treatment. It will be delivered either as a pericoital vaginal gel in hydroxyethyl cellulose (HEC) or a long-acting vaginal ring.
Product Details
Delivery Method: ,
Duration Type: ,
Active Pharmaceutical Ingredient (API):
Inactive material: silicone; hydroxyethyl cellulose
Status Details
Began discovery in: 2008
Status Details: - Preliminary work indicated that 70% of female mice vaginally administered with this LL-37 gel did not become pregnant following natural mating. A higher concentration gel will be tested. The female reproductive tract tissues will be observed for intactness and the presence of recruited immune cells.
- Preliminary work indicated that 70% of female mice vaginally administered with this LL-37 gel did not become pregnant following natural mating. A higher concentration gel will be tested. The female reproductive tract tissues will be observed for intactness and the presence of recruited immune cells.
Additional Information
References: Srakaew N, et al. (2014) Antimicrobial host defence peptide, LL-37, as a potential vaginal contraceptive. Human Reproduction. 29 (4):683-96.
Srakaew N, et al. (2014) Antimicrobial host defence peptide, LL-37, as a potential vaginal contraceptive. Human Reproduction. 29 (4):683-96.