Polidocanol
Alternative Name: Polidocanol Foam Permanent Contraception
Description: Polidocanol is a synthetic, long-chain fatty acid that is used as a vein sclerosing agent in Europe and the United States. A foam preparation increases activity without increasing overall dose. Following transcervical administration of polidocanol foam into the uterine cavity, the foam moves into the fallopian tube. This results in epithelial damage followed by connective tissue scaring and tubal occlusion confined to the intramural (uterine wall) portion of the tube.
Product Details
Duration: Permanent
Regimen:
Active Pharmaceutical Ingredient (API):
Status Details
Began discovery in: 2004
Status Details: - A pilot study has been conducted in non-human primates.
- A pilot study has been conducted in non-human primates.
Additional Information
References: Jensen JT. (2014) Blockade of tubal patency following transcervical administration of polidocanol foam: initial studies in rhesus macaques. Contraception. 89(6):540-9.
Jensen JT, et al. (2016) Transcervical administration of polidocanol foam prevents pregnancy in female baboons. Contraception. 94(5); 527-533.
Jensen JT. (2014) Blockade of tubal patency following transcervical administration of polidocanol foam: initial studies in rhesus macaques. Contraception. 89(6):540-9.
Jensen JT, et al. (2016) Transcervical administration of polidocanol foam prevents pregnancy in female baboons. Contraception. 94(5); 527-533.