Alternative Name: Polidocanol Foam Permanent Contraception

Description: Polidocanol is a synthetic, long-chain fatty acid that is used as a vein sclerosing agent in Europe and the United States. A foam preparation increases activity without increasing overall dose. Following transcervical administration of polidocanol foam into the uterine cavity, the foam moves into the fallopian tube. This results in epithelial damage followed by connective tissue scaring and tubal occlusion confined to the intramural (uterine wall) portion of the tube.

Product Details

User: Female

Hormonal: No

Delivery Method: Fallopian Tube

Duration Type: Permanent

Duration: Permanent

  • single administration

Active Pharmaceutical Ingredient (API):
  • polidocanol

Multipurpose Preventive Technology (MPT): No

Status Details

Developer: Oregon Health & Science University

Project Phase: Pre-Clinical and Clinical Development

Development Stage: Pre-clinical

Began discovery in: 2004

Active Development: Yes

Status Details:
  • A pilot study has been conducted in non-human primates.

Additional Information

  • Jensen JT. (2014) Blockade of tubal patency following transcervical administration of polidocanol foam: initial studies in rhesus macaques. Contraception. 89(6):540-9.

  • Jensen JT, et al. (2016) Transcervical administration of polidocanol foam prevents pregnancy in female baboons. Contraception. 94(5); 527-533.

Vertical Tabs