Prostaglandin E2 Receptor

Alternative Name: PGE2

Description: Prostaglandin E2 is critical for follicle rupture and the expansion of the cumulus granulosa cells surrounding the oocyte. Therefore, blocking prostaglandin synthesis and signaling is expected to block oocyte release, as well as inhibit cumulus expansion and fertilization.

Target

Product Details

User: Female

Hormonal: No

Active Pharmaceutical Ingredient (API):
  • Prostaglandin E2 Receptor Antagonist

Role in reproduction: Oocyte Maturation

Multipurpose Preventive Technology (MPT): No

Status Details

Developer: Oregon Health & Science University, Bayer HealthCare

Project Phase: Discovery and Early Development

Development Stage: Target Identification

Began discovery in: 2007

Active Development: Yes

Status Details:
  • In vitro studies established an important role for PGE2 in regulating primate ovarian activities necessary for fertilization, including the expansion of the somatic cells that surround the oocyte and follicle rupture.
  • Proof-of-principle studies conducted in cynomolgus macaques revealed a selective PGE2 receptor type 2 antagonist significantly reduced pregnancy rates.

Additional Information

References:
  • Peluffo MC, et al. (2014) A prostaglandin E2 receptor antagonist prevents pregnancies during a preclinical contraceptive trial with female macaques. Hum Reprod. 29:1400-12.

  • Edelman AB, et al. (2013) Impact of the prostaglandin synthase-2 inhibitor celecoxib on ovulation and luteal events in women. Contraception. 87:352-7.

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