Prostaglandin E2 Receptor
Alternative Name: PGE2
Description: Prostaglandin E2 is critical for follicle rupture and the expansion of the cumulus granulosa cells surrounding the oocyte. Therefore, blocking prostaglandin synthesis and signaling is expected to block oocyte release, as well as inhibit cumulus expansion and fertilization.
Target
Product Details
User: Female
Hormonal: No
Active Pharmaceutical Ingredient (API): - Prostaglandin E2 Receptor Antagonist
- Prostaglandin E2 Receptor Antagonist
Role in reproduction: Oocyte Maturation
Multipurpose Preventive Technology (MPT): No
Status Details
Developer: Oregon Health & Science University, Bayer HealthCare
Project Phase: Discovery and Early Development
Development Stage: Target Identification
Began discovery in: 2007
Active Development: Yes
Status Details: - In vitro studies established an important role for PGE2 in regulating primate ovarian activities necessary for fertilization, including the expansion of the somatic cells that surround the oocyte and follicle rupture.
- Proof-of-principle studies conducted in cynomolgus macaques revealed a selective PGE2 receptor type 2 antagonist significantly reduced pregnancy rates.
- In vitro studies established an important role for PGE2 in regulating primate ovarian activities necessary for fertilization, including the expansion of the somatic cells that surround the oocyte and follicle rupture.
- Proof-of-principle studies conducted in cynomolgus macaques revealed a selective PGE2 receptor type 2 antagonist significantly reduced pregnancy rates.
Additional Information
References: Peluffo MC, et al. (2014) A prostaglandin E2 receptor antagonist prevents pregnancies during a preclinical contraceptive trial with female macaques. Hum Reprod. 29:1400-12.
Edelman AB, et al. (2013) Impact of the prostaglandin synthase-2 inhibitor celecoxib on ovulation and luteal events in women. Contraception. 87:352-7.
Peluffo MC, et al. (2014) A prostaglandin E2 receptor antagonist prevents pregnancies during a preclinical contraceptive trial with female macaques. Hum Reprod. 29:1400-12.
Edelman AB, et al. (2013) Impact of the prostaglandin synthase-2 inhibitor celecoxib on ovulation and luteal events in women. Contraception. 87:352-7.