Prostaglandin E2 Receptor Antagonists

Product Overview

Alternative Name: Prostaglandin E2 (PGE2) Synthesis / Signaling inhibitors

Development Status: Active Development

Target: Female

Mode: Non-hormonal

Delivery Type: TBD

Duration Type: TBD

Description: Prostaglandin E2 is critical for follicle rupture and the expansion of the cumulus granulosa cells surrounding the oocyte. Therefore, blocking prostaglandin synthesis and signaling is expected to block oocyte release, as well as inhibit cumulus expansion and fertilization.

Updated date: July 26, 2016

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Project Phase: Discovery

Project Stage: Target ID/Validation

Began discovery in: 2007

Status Details:
  • In vitro studies established an important role for PGE2 in regulating primate ovarian activities necessary for fertilization, including the expansion of the somatic cells that surround the oocyte and follicle rupture.
  • Proof-of-principle studies conducted in cynomolgus macaques revealed a selective PGE2 receptor type 2 antagonist significantly reduced pregnancy rates.

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