Alternative Name: Retinoic acid receptor (RAR) antagonists
Description: Vitamin A (dietary retinol) is essential for normal spermatogenesis. Defects in spermatogenesis (as a result of RARa knock-out) include failure of spermatids to align and be released into the lumen, and presumably reflecting aberrant orientation to the Sertoli cells. However, the molecular mechanisms underlying retinol regulation of spermatogensis remains to be elucidated.
Updated date: May 30, 2018