Alternative Name: Serum- and Glucocorticoid-Regulated Kinase
Description: SGK-1 (serum- and glucocorticoid-regulated kinase) is aberrantly expressed in mid-secretory endometrium of women with unexplained infertility. In normal cycle, SGK-1 is suppressed at midcycle by AKT.
Role in reproduction: Implantation
Multipurpose Preventive Technology (MPT): No
Project Phase: Discovery and Early Development
Development Stage: Target Identification
Active Development: Unknown
- Over-expression of SGK-1 in mice resulted in an infertile phenotype. Tests are underway with known inhibitors of AKT to determine whether such inhibition will lead to an inappropriate increase in SGK-1 and failure of implantation.