SGK-1 / AKT

Alternative Name: Serum- and Glucocorticoid-Regulated Kinase

Description: SGK-1 (serum- and glucocorticoid-regulated kinase) is aberrantly expressed in mid-secretory endometrium of women with unexplained infertility. In normal cycle, SGK-1 is suppressed at midcycle by AKT.

Target

Product Details

User: Female

Hormonal: No

Role in reproduction: Implantation

Multipurpose Preventive Technology (MPT): No

Status Details

Developer: CONRAD, Imperial College, London

Project Phase: Discovery and Early Development

Development Stage: Target Identification

Active Development: Unknown

Status Details:
  • Over-expression of SGK-1 in mice resulted in an infertile phenotype. Tests are underway with known inhibitors of AKT to determine whether such inhibition will lead to an inappropriate increase in SGK-1 and failure of implantation.

Additional Information

References:

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