Testicular Ultrasound

Description: Application of therapeutic ultrasound to testes.

Product Details

User: Male

Hormonal: No

Delivery Method: Testicular

Duration Type: Permanent, Short-acting

Duration: 6 months

  • single

Multipurpose Preventive Technology (MPT): No

Status Details

Developer: Parsemus Foundation, University of Bari, University of California, University of North Carolina at Chapel Hill

Project Phase: Pre-Clinical and Clinical Development

Development Stage: Pre-clinical

Began discovery in: 1970s

Active Development: No

Status Details:
  • Already tested in multiple species for efficacy, toxicology, and genotoxicity. The method provides permanent sterilization in rats and dogs, but transient contraception in monkeys. Obtaining a long-lasting effect in humans has not yet been found.
  • Initial work on this method was conducted in the 1970s at the University of Missouri at Columbia. In 2010, researchers at UNC-Chapel Hill won a grant to study the method in rats. Parsemus Foundation is funding an Italian team who worked on dogs and a team at the University of California who worked on monkeys.

Additional Information

  • Parsemus Foundation website: http://www.parsemus.org/projects/ultrasound/

  • VandeVoort CA, Tollner TL. (2012) The efficacy of ultrasound treatment as a reversible male contraceptive in the rhesus monkey. Reprod Biol Endocrinol. 10:81.

  • Tsuruta JK, Dayton PA, et al. (2012) Therapeutic ultrasound as a potential male contraceptive: power, frequency and temperature required to deplete rat testes of meiotic cells and epididymides of sperm determined using a commercially available system. Reprod Biol Endocrinol. 10:7.

  • Leoci R, Aiudi G, et al. (2015) Therapeutic ultrasound as a potential male dog contraceptive: determination of the most effective application protocol. Reprod Domest Anim. 50(5):712-8.

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