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UPA Vaginal Ring
Ulipristal acetate (UPA) vaginal ring
A vaginal ring that delivers ulipristal acetate (UPA) daily. UPA is a progesterone receptor modulator (PMR) approved for use by the US FDA as an oral emergency contraceptive pill (EllaOne) and in the EU for uterine fibroid treatment. Ring is a silicone elastomer fusion technology of a ring within a ring.
May 30, 2018
Active Pharmaceutical Ingredient (API):
Potential Multi-Purpose Technology (MPT):
One ring for 3 months
Began discovery in:
Phase IIa dose-finding study has been completed. Effective dose identified. Additional long-term studies to confirm safety in preparation.
UPA does not stimulate breast cell multiplication and, in contrast with progestins, it may prevent breast diseases. This will require long-term studies to be confirmed.
PRM associated endometrial changes (PAEC) occur but are totally reversible. Research ongoing for a method to prevent appearance of PAEC.
HRA Pharma website:
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