Alternative Name: S-003296
Description: In testing, the new compound killed 100% sperm in less than 30 seconds but did not affect human cervical (HeLa) cell viability up to 24 hours. S-003-296 did not inhibit Lactobacillus growth and exhibited a mild microbicidal activity against Trichomonoas vaginalis. The compound caused a very “physiological” and mechanism-based sperm death by hyperpolarizing membrane potential, increasing intracellular pH, inhibition of tyrosine phosphorylation and induction of apoptosis without physically disrupting the plasma membrane integrity.
Updated date: June 27, 2017