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Vaginal Spermicide (S-003-296)
In testing, the new compound killed 100% sperm in less than 30 seconds but did not affect human cervical (HeLa) cell viability up to 24 hours. S-003-296 did not inhibit Lactobacillus growth and exhibited a mild microbicidal activity against Trichomonoas vaginalis. The compound caused a very “physiological” and mechanism-based sperm death by hyperpolarizing membrane potential, increasing intracellular pH, inhibition of tyrosine phosphorylation and induction of apoptosis without physically disrupting the plasma membrane integrity.
June 27, 2017
Potential Multi-Purpose Technology (MPT):
20 µg/ml; doses of 1mg and 2mg were tested on rabbits
Central Drug Research Institute, India
Central Drug Research Institute website:
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