Vaginal Spermicide (S-003-296)
Alternative Name: S-003296
Description: In testing, the new compound killed 100% sperm in less than 30 seconds but did not affect human cervical (HeLa) cell viability up to 24 hours. S-003-296 did not inhibit Lactobacillus growth and exhibited a mild microbicidal activity against Trichomonoas vaginalis. The compound caused a very "physiological" and mechanism-based sperm death by hyperpolarizing membrane potential, increasing intracellular pH, inhibition of tyrosine phosphorylation and induction of apoptosis without physically disrupting the plasma membrane integrity.
Product Details
Duration: Single use
Regimen:
Dose: 20 µg/ml; doses of 1mg and 2mg were tested on rabbits
Status Details
Additional Information
References: Central Drug Research Institute website: www.cdri.res.in/
Central Drug Research Institute website: www.cdri.res.in/