Vaginal Spermicide (S-003-296)

Alternative Name: S-003296

Description: In testing, the new compound killed 100% sperm in less than 30 seconds but did not affect human cervical (HeLa) cell viability up to 24 hours. S-003-296 did not inhibit Lactobacillus growth and exhibited a mild microbicidal activity against Trichomonoas vaginalis. The compound caused a very "physiological" and mechanism-based sperm death by hyperpolarizing membrane potential, increasing intracellular pH, inhibition of tyrosine phosphorylation and induction of apoptosis without physically disrupting the plasma membrane integrity.

Product Details

User: Female

Hormonal: No

Delivery Method: Vaginal Gel

Duration Type: Pericoital

Duration: Single use

Regimen:
  • Before intercourse

Dose: 20 µg/ml; doses of 1mg and 2mg were tested on rabbits

Multipurpose Preventive Technology (MPT): Yes

Status Details

Developer: Central Drug Research Institute, India

Project Phase: Pre-Clinical and Clinical Development

Development Stage: Pre-clinical

Active Development: Unknown

Additional Information

References:

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