Alternative Name: WEE1 HOMOLOG 2, WEE1B, WEE2 Kinase
Description: WEE2 phosphorylates and inhibits CDC2, which is a catalytic subunit of metaphase promoting factor (MPF) and thus, acts as a negative regulator of oocyte maturation and fertilization. WEE2 is specifically expressed in the oocyte in mice, rhesus macaques, and humans. Inhibition of WEE2 prevents final meiotic maturation of the oocyte (metaphase II arrest) and consequently blocks fertilization.
Updated date: May 30, 2018