Acyline
Alternative Name: GnRH II Receptor Antagonists
Description: A gonadotropin-releasing hormone II analog, acyline, has been developed. It is proposed that the contraceptive action of GnRH AIIA is through down-regulation of the GnRH II receptor. Further work is required to understand the full complexity of the antagonists action.
Product Details
Reference target/product: GnRH II Receptor
Status Details
Developer: ,
Additional Information
References: Valiente C, et al. (2009) Comparison of two doses of the GnRH antagonist, acyline, for pregnancy termination in bitches. Reprod Domest Anim. 44(Suppl 2):156-9.
Herbst, KL, et al. (2002). Acyline: the first study in humans of a potent, new gonadotropin-releasing hormone antagonist. The Journal of Clinical Endocrinology & Metabolism, 87(7), 3215-3220.
Valiente C, et al. (2009) Comparison of two doses of the GnRH antagonist, acyline, for pregnancy termination in bitches. Reprod Domest Anim. 44(Suppl 2):156-9.
Herbst, KL, et al. (2002). Acyline: the first study in humans of a potent, new gonadotropin-releasing hormone antagonist. The Journal of Clinical Endocrinology & Metabolism, 87(7), 3215-3220.