Acyline

Alternative Name: GnRH II Receptor Antagonists

Description: A gonadotropin-releasing hormone II analog, acyline, has been developed. It is proposed that the contraceptive action of GnRH AIIA is through down-regulation of the GnRH II receptor. Further work is required to understand the full complexity of the antagonists action.

Product Details

Hormonal: Yes

Multipurpose Preventive Technology (MPT): No

Reference target/product: GnRH II Receptor

Status Details

Developer: CICRR, San Antonio, CONRAD

Project Phase: Discovery and Early Development

Development Stage: Compound ID/Selection

Active Development: Unknown

Additional Information

References:
  • Valiente C, et al. (2009) Comparison of two doses of the GnRH antagonist, acyline, for pregnancy termination in bitches. Reprod Domest Anim. 44(Suppl 2):156-9.

  • Herbst, KL, et al. (2002). Acyline: the first study in humans of a potent, new gonadotropin-releasing hormone antagonist. The Journal of Clinical Endocrinology & Metabolism, 87(7), 3215-3220.

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