ADAM2

Alternative Name: ADAM Metallopeptidase Domain 2, Fertilin β, Cancer/Testis Antigen 15, Disintegrin And Metalloproteinase Domain-Containing Protein 2, PH30-Beta, FTNB, CT15, PH30, EC 3.4.24, PH-30b, CRYN1, CRYN2, PH-30

Description: ADAM2 belongs to a disintegrin and metalloprotease domain-containing family of multidomain membrane proteins comprising of over 34 members. A majority of these proteins are predominantly expressed in the mammalian male reproductive tract, implying a role in male reproduction. ADAM2 is enriched in the human testis and ovary. ADAM2 has been demonstrated to form functional complexes with specific ADAM family members, and the ADAM2-ADAM3 complex is suggested to play a role in both sperm migration in the mouse female reproductive tract and in sperm-egg interaction. In humans however, ADAM2 expression was observed in the testis, but not in sperm, suggesting differing reproductive functions of ADAM2 in humans and mice.

Target

Product Details

User: Female, Male

Hormonal: No

Role in reproduction: Sperm-Egg Interaction, Spermatogenesis, Sperm Function

Multipurpose Preventive Technology (MPT): No

Status Details

Project Phase: Discovery and Early Development

Development Stage: Target Validation

Began discovery in: 1996

Additional Information

References:
  • Cho, C. (1998). Fertilization Defects in Sperm from Mice Lacking Fertilin. Science,281(5384), 1857-1859.

  • Choi, H., Jin, S., Kwon, J. T., Kim, J., Jeong, J., Kim, J., . . . Cho, C. (2016). Characterization of Mammalian ADAM2 and Its Absence from Human Sperm. Plos One,11(6).

  • Depa-Martynów, M., Kempisty, B., Lianeri, M., Jagodziński, P. P., & Jedrzejczak, P. (2007). Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos.

  • Folia Histochemica, 45 (Supp. 1), 79-85. Seals, D. F. (2003). The ADAMs family of metalloproteases: Multidomain proteins with multiple functions. Genes & Development,17(1), 7-30.

  • Yamaguchi, R., Fujihara, Y., Ikawa, M., & Okabe, M. (2012). Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa. Molecular Biology of the Cell,23(14), 2671-2679.

  • Cho, C. (2012). Testicular and epididymal ADAMs: Expression and function during fertilization. Nature Reviews Urology, 9(10), 550-560.

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