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Adjudin specifically affects germ cell adhesion, most notably elongating and elongated spermatids shown in rats, rabbits and beagle dogs. Thus, adjudin induces premature exfoliation of sperms from the seminiferoous epithelium. This leads to a lack of mature spermatozoa in ejaculate and ultimately infertility. Adjudin, as well as H2-Gamendazole, are derivatives of lonidamine. Since adjudin does not deplete the population of undifferentiated spermatogonia or spermatogonial stem cells, spermatogenesis eventually resumes and fertility rebounds.
May 30, 2018
Active Pharmaceutical Ingredient (API):
Potential Multi-Purpose Technology (MPT):
Once a week; After 2 doses, effective for transient and reversible infertility
Laboratory rats remain infertile after 2 doses for approximately 4 weeks
Contraceptive efficacy has been proven in vivo in rats, rabbits, and beagle dogs.
Work is in progress to assess the efficacy and optimal dose(s) of adjudin-inclusion mixture B formulation. Also under assessment is a formulation that requires a multi-drug approach using adjudin with an F5-peptide endogenously produced in the testis in vivo.
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