Product Overview

Alternative Name: AF-2364

Development Status: Active Development

Target: Male

Mode: Non-hormonal

Delivery Type: TBD

Duration Type: Short-acting

Description: Adjudin specifically affects germ cell adhesion, most notably elongating and elongated spermatids shown in rats, rabbits and beagle dogs. Thus, adjudin induces premature exfoliation of sperms from the seminiferoous epithelium. This leads to a lack of mature spermatozoa in ejaculate and ultimately infertility. Adjudin, as well as H2-Gamendazole, are derivatives of lonidamine. Since adjudin does not deplete the population of undifferentiated spermatogonia or spermatogonial stem cells, spermatogenesis eventually resumes and fertility rebounds.

Updated date: May 30, 2018

Vertical Tabs


Project Phase: Early Development

Project Stage: Lead Optimization

Status Details:
  • Contraceptive efficacy has been proven in vivo in rats, rabbits, and beagle dogs.

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