Adjudin
Alternative Name: AF-2364
Description: Adjudin specifically affects germ cell adhesion, most notably elongating and elongated spermatids shown in rats, rabbits and beagle dogs. Thus, adjudin induces premature exfoliation of sperms from the seminiferoous epithelium. This leads to a lack of mature spermatozoa in ejaculate and ultimately infertility. Adjudin, as well as H2-Gamendazole, are derivatives of lonidamine. Since adjudin does not deplete the population of undifferentiated spermatogonia or spermatogonial stem cells, spermatogenesis eventually resumes and fertility rebounds.
Product Details
User: Female, Male
Hormonal: No
Delivery Method: Injectable, Oral, Other
Duration Type: Short-acting
Duration: Laboratory rats remain infertile after 2 doses for approximately 4 weeks
Regimen: - Once a week; After 2 doses, effective for transient and reversible infertility
- Once a week; After 2 doses, effective for transient and reversible infertility
Active Pharmaceutical Ingredient (API): - 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide
- 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide
Role in reproduction: Spermatogenesis
Multipurpose Preventive Technology (MPT): No
Status Details
Developer: Population Council
Project Phase: Discovery and Early Development
Development Stage: Lead Optimization
Active Development: Yes
Status Details: - Contraceptive efficacy has been proven in vivo in rats, rabbits, and beagle dogs.
- Contraceptive efficacy has been proven in vivo in rats, rabbits, and beagle dogs.
Additional Information
References: Population Council website: http://www.popcouncil.org/research/development-of-adjudin-as-a-male-cont...
Population Council website: http://www.popcouncil.org/research/development-of-adjudin-as-a-male-cont...