Androgen Restored Contraceptive

Alternative Name: ARC; triple hormone contraceptive; Triple OC

Description: Androgen restored contraceptive consists of prasterone, estradiol, and progesterone. By adding the natural human androgen dehydroepiandrosterone (DHEA) to an oral contraceptive (OC), the developers anticipate to minimize subjective side effects such as mood changes, decrease of sexual desire, and risk of venous thromboembolic events. Addition of a suitable formulation and dose of DHEA normalizes testosterone (T) levels during OC use and is expected to counteract the clinical consequences of T-deficiency.

Product Details

Duration: One day


Active Pharmaceutical Ingredient (API):

Status Details

Developer: ,

Status Details:
  • A phase II trial to test efficacy and safety has been completed.

Additional Information

  • Zimmerman Y. et al. (2015) Restoring testosterone levels by adding dehydroepiandrosterone to a drospirenone containing combined oral contraceptive. Contraception. 91(2) 127-142.

  • Coelingh Bennink HJT, et al. (2017) Maintaining physiological testosterone levels by adding dehydroepiandrosterone to combined oral contraceptives: I. Endocrine effects. Contraception. 96(5); 322-329.

  • Pantarhei Bioscience website:

Vertical Tabs