Annovera™
Alternative Name: Nestorone + Ethinyl Estradiol One-Year Contraceptive Vaginal Ring, NES + EE Vaginal Ring
Description: The one-year contraceptive vaginal ring contains ethinyl estradiol (EE) and Nestorone® (NES), in a silicone elastomer ring with 2 cores. It is left in place for 21 days and removed for seven days, for up to 13 cycles (one-year).
Product Details
User: Female
Hormonal: Yes
Delivery Method: Vaginal Ring
Duration Type: Long-acting
Duration: One year
Regimen: - Three weeks in and one week out for 13 cycles
- Three weeks in and one week out for 13 cycles
Dose: 150µg NES, 15µg EE per day
Active Pharmaceutical Ingredient (API): - nestorone
- ethinyl estradiol
- nestorone
- ethinyl estradiol
Inactive material: silicone elastomer
Multipurpose Preventive Technology (MPT): No
Status Details
Developer: Population Council, NICHD, WHO, USAID, NIH, Bill & Melinda Gates Foundation, Avis and Clifford Barrus Medical Foundation
Project Phase: Limited Market Availability
Development Stage: SRA/WHO PQ Approved
Began discovery in: 1990's
Active Development: Yes
Status Details: - In August 2018, the FDA approved the NES +EE vaginal ring with the marketed name of Annovera.
- The Population Council is pursuing regulatory approval in low and middle-income countries, with funding from their USAID project, Delivering a Family of Contraceptive Vaginal Rings.
- In August 2018, the FDA approved the NES +EE vaginal ring with the marketed name of Annovera.
- The Population Council is pursuing regulatory approval in low and middle-income countries, with funding from their USAID project, Delivering a Family of Contraceptive Vaginal Rings.
Additional Information
References: Annovera website: annovera.com
Archer DF, et al. (2019). Efficacy of the 1-year (13-cycle) segesterone acetate and ethinylestradiol contraceptive vaginal system: results of two multicentre, open-label, single-arm, phase 3 trials. Lancet Glob Health. 7(8):e1054-e1064. doi:10.1016/S2214-109X(19)30265-7. PMID: 31231065.
Population Council website: https://www.popcouncil.org/research/one-year-contraceptive-vaginal-ring
Annovera website: annovera.com
Archer DF, et al. (2019). Efficacy of the 1-year (13-cycle) segesterone acetate and ethinylestradiol contraceptive vaginal system: results of two multicentre, open-label, single-arm, phase 3 trials. Lancet Glob Health. 7(8):e1054-e1064. doi:10.1016/S2214-109X(19)30265-7. PMID: 31231065.
Population Council website: https://www.popcouncil.org/research/one-year-contraceptive-vaginal-ring