BRDT
Alternative Name: Bromodomain Testis Associated, Cancer/Testis Antigen 9, Bromodomain Testis-Specific Protein, Bromodomain, Testis-Specific, RING3-Like Protein, CT9, SPGF21, BRD6
Description: BRDT is a transcriptional regulator that belongs to the bromodomain and extra-terminal (BET) subfamily of epigenetic reader proteins. BRDT is predominantly expressed in the testis and is also observed in the mouse pituitary gland. BRDT is involved in chromatin organization and transcriptional regulation during spermatogenesis. It is also shown to play a role in scheduling male puberty through the regulation of the pituitary-gonadal axis. BRDT-null male mice are infertile and demonstrate severe reproductive phenotypes. The small molecule, JQ1, is a lead compound in targeting BRDT.
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References: Matzuk, M., Mckeown, M., Filippakopoulos, P., Li, Q., Ma, L., Agno, J., . . . Bradner, J. (2012). Small-Molecule Inhibition of BRDT for Male Contraception. Cell,150(4), 673-684.
Aston, K.I., Krausz, C., Laface, I., Ruiz-Castane, E., Carrell, D.T. (2010). Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. Hum. Reprod. 25, 1383e1397.
Barda, S., Yogev, L., Paz, G., Yavetz, H., Hauser, R., Breitbart, H., & Kleiman, S. E. (2016). New insights into the role of the Brdt protein in the regulation of development and spermatogenesis in the mouse. Gene Expression Patterns,20(2), 130-137.
Plaseski, T., Noveski, P., Popeska, Z., Efremov, G.D., Plaseska-Karanfilska, D. (2012). Association study of single-nucleotide polymorphisms in FASLG, JMJDIA, LOC203413, TEX15, BRDT, OR2W3, INSR, and TAS2R38 genes with male infertility. J. Androl. 33, 675e683.
Matzuk, M., Mckeown, M., Filippakopoulos, P., Li, Q., Ma, L., Agno, J., . . . Bradner, J. (2012). Small-Molecule Inhibition of BRDT for Male Contraception. Cell,150(4), 673-684.
Aston, K.I., Krausz, C., Laface, I., Ruiz-Castane, E., Carrell, D.T. (2010). Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. Hum. Reprod. 25, 1383e1397.
Barda, S., Yogev, L., Paz, G., Yavetz, H., Hauser, R., Breitbart, H., & Kleiman, S. E. (2016). New insights into the role of the Brdt protein in the regulation of development and spermatogenesis in the mouse. Gene Expression Patterns,20(2), 130-137.
Plaseski, T., Noveski, P., Popeska, Z., Efremov, G.D., Plaseska-Karanfilska, D. (2012). Association study of single-nucleotide polymorphisms in FASLG, JMJDIA, LOC203413, TEX15, BRDT, OR2W3, INSR, and TAS2R38 genes with male infertility. J. Androl. 33, 675e683.