CABYR

Alternative Name: Calcium Binding Tyrosine Phosphorylation Regulated, Cancer/Testis Antigen 88, Calcium-Binding Tyrosine Phosphorylation-Regulated Protein, Testis-Specific Calcium-Binding Protein CBP86, Calcium-Binding Protein 86, Fibrousheathin II, Fibrousheathin-2, CBP86, FSP-2, CT88, FSP2

Description: CABYR is a protein in the fibrous sheath of the principle piece of the flagellum and is phosphorylated during capacitation. CABYR-KO male mice and severely subfertile. CABYR appears to be involved in the development of the fibrous sheath during spermiogenesis and possibly signal transduction, regulation of flagellar motility, capacitation, and the acrosome reaction. In-vitro assays suggest CABYR-KO spermatozoa have impaired zona pellucida binding, possibly due to motility defects, but not oolemma interactions

Target

Product Details

User: Female, Male

Hormonal: No

Role in reproduction: Spermatogenesis, Sperm Function

Multipurpose Preventive Technology (MPT): No

Status Details

Project Phase: Discovery and Early Development

Development Stage: Target Validation

Additional Information

References:
  • Li YF, He W, Mandal A, Kim YH, Digilio L, Klotz K, Flickinger CJ, Herr JC. CABYR binds to AKAP3 and Ropporin in the human sperm fibrous sheath. Asian J Androl. 2011 Mar; 13(2): 266–274. PMID: 21240291

  • Naaby-Hansen, S., Mandal, A., Wolkowicz, M. J., Sen, B., Westbrook, V. A., Shetty, J., Coonrod, S. A., Klotz, K. L., Kim, Y.-H., Bush, L. A. et al. (2002). CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation. Dev. Biol. 242, 236-254. doi:10.1006/dbio.2001.0527. PMID: 11820818.

  • Young SA, Miyata H, Satouh Y, Aitken RJ, Baker MA, Ikawa M. CABYR is essential for fibrous sheath integrity and progressive motility in mouse spermatozoa. J Cell Sci. 2016 Dec 1;129(23):4379-4387. doi: 10.1242/jcs.193151. PMID: 27802166

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