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Description: CatSper is a calcium-selective ion channel confined to the tail of mature sperm. CatSper is required for hyperactivated sperm motility and thus fertilization. CatSper is encoded by four distinct genes, CatSper1-4, which form the pore of the channel. Additional subunits are also required for proper assembly of the channel along a quadrilateral complex from the sperm midpiece to end of the tail. Mutant CatSper genes in humans are associated with male infertility.
Small molecule screens have yielded CatSper blockers. These require refining for potency, specificity, and pharmacokinetics.
Updated date: May 30, 2018