Desogestrel + Testosterone | The Contraceptive Pipeline Database

Product Overview

Development Status: Inactive

Target: Male

Mode: Hormonal

Delivery Type: Oral, Subdermal

Duration Type: Long-acting

Description: Combined male contraceptive using desogestrel and testosterone. Pilot work used oral desogestrel and depot testosterone, but further development would likely use a combined depot approach.

Updated date: May 30, 2018

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Product Details

Active Pharmaceutical Ingredient (API): testosterone, desogestrel

Potential Multi-Purpose Technology (MPT): No

Regimen: Daily oral desogestrel, testosterone depot every 3 months

Dose: 300mcg desogestrel, 300mg testosterone

Partner: University of Edinburgh

Status

Project Phase: Late Development

Project Stage: Phase II

Began discovery in: 1995

Status Details:
While pilot work showed that this is a promising approach that could be taken further, no further development is currently taking place.

Programmatic Considerations

Additional Information

Additional Information:
Kinniburgh D, Zhu H, et al. (2002) Oral desogestrel with testosterone pellets induces consistent suppression of spermatogenesis to azoospermia in both Caucasian and Chinese men. Human Reprod 17,1490-1501.

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