Desogestrel + Testosterone

Description: Combined male contraceptive using desogestrel and testosterone. Pilot work used oral desogestrel and depot testosterone, but further development would likely use a combined depot approach.

Product Details

User: Male

Hormonal: Yes

Delivery Method: Oral, Subdermal

Duration Type: Short-acting

  • Daily oral desogestrel, testosterone depot every 3 months

Dose: 300mcg desogestrel, 300mg testosterone

Active Pharmaceutical Ingredient (API):
  • testosterone
  • desogestrel

Multipurpose Preventive Technology (MPT): No

Status Details

Developer: University of Edinburgh

Project Phase: Pre-Clinical and Clinical Development

Development Stage: Phase II

Began discovery in: 1995

Active Development: No

Status Details:
  • While pilot work showed that this is a promising approach that could be taken further, no further development is currently taking place.

Additional Information

  • Kinniburgh D, et al. (2002) Oral desogestrel with testosterone pellets induces consistent suppression of spermatogenesis to azoospermia in both Caucasian and Chinese men. Human Reprod. 17:1490-1501.

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