Gossypol

Description: Gossypol is a plant-derived compound taken orally that decreases sperm counts in men.

Product Details

User: Male

Hormonal: No

Delivery Method: Oral

Duration Type: Permanent, Short-acting

Regimen:
  • daily

Multipurpose Preventive Technology (MPT): No

Status Details

Developer: WHO, South-to-South Cooperation in Reproductive Health

Project Phase: Pre-Clinical and Clinical Development

Development Stage: Phase I

Began discovery in: 1970's

Active Development: No

Status Details:
  • In 1986, WHO discontinued research on this drug as lingering questions about toxicity were in question as well as the reversability (almost 40% of men did not regain fertility). Research continued in Brazil and elsewhere at least through 2000.

Additional Information

References:
  • Coutinho EM. (2002). Gossypol: a contraceptive for men. Contraception. 65(4):259-263.

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