LIF and IL - 11
Alternative Name: Leukemia inhibitory factor (LIF) and interleukin-11 (IL-11)
Description: Leukemia inhibitory factor (LIF) and interleukin-11 (IL-11) both belong to the IL-6 family of cytokines. In mice lacking LIF, females were infertile as a result of inability of blastocysts to implant in the uterus. In mice lacking the ?-subunit of the IL-11 receptor, females were infertile as a disturbance to the decidualization process.
Product Details
Status Details
Status Details: - Small peptide antagonists to LIF receptor have been developed and were shown to block implantation in mouse models
- however, due to their short half-life in vivo, they had to be frequently administered.
- A PEGlyated version has been developed but further formulation refinement is needed for additional testing.
- Similar technology used to create the LIF receptor antagonist has been using to create an IL-11 receptor antagonists, but in vivo tests have not yet been completed.
- The formulation of PEGlyated LIF receptor antagonist needs to be refined and proof-of-principle established in vivo.
- Small peptide antagonists to LIF receptor have been developed and were shown to block implantation in mouse models
- however, due to their short half-life in vivo, they had to be frequently administered.
- A PEGlyated version has been developed but further formulation refinement is needed for additional testing.
- Similar technology used to create the LIF receptor antagonist has been using to create an IL-11 receptor antagonists, but in vivo tests have not yet been completed.
- The formulation of PEGlyated LIF receptor antagonist needs to be refined and proof-of-principle established in vivo.
Additional Information
References: Sengupta J, Lalitkumar PG, et al. (2006) Monoclonal anti-leukemia inhibitory factor antibody inhibits blastocyst implantation in the rhesus monkey. Contraception. 74:419-425
Sengupta J, Lalitkumar PG, et al. (2006) Monoclonal anti-leukemia inhibitory factor antibody inhibits blastocyst implantation in the rhesus monkey. Contraception. 74:419-425