LIF and IL - 11

Product Overview

Alternative Name: Leukemia inhibitory factor (LIF) and interleukin-11 (IL-11)

Development Status: Inactive

Target: Female

Mode: Non-hormonal

Duration Type: Short-acting

Description: Leukemia inhibitory factor (LIF) and interleukin-11 (IL-11) both belong to the IL-6 family of cytokines. In mice lacking LIF, females were infertile as a result of inability of blastocysts to implant in the uterus. In mice lacking the ą-subunit of the IL-11 receptor, females were infertile as a disturbance to the decidualization process.

Updated date: May 30, 2018

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Status

Project Phase: Discovery

Project Stage: Target ID/Validation

Status Details:
  • Small peptide antagonists to LIF receptor have been developed and were shown to block implantation in mouse models; however, due to their short half-life in vivo, they had to be frequently administered.
  • A PEGlyated version has been developed but further formulation refinement is needed for additional testing.
  • Similar technology used to create the LIF receptor antagonist has been using to create an IL-11 receptor antagonists, but in vivo tests have not yet been completed.
  • The formulation of PEGlyated LIF receptor antagonist needs to be refined and proof-of-principle established in vivo.

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