LIF and IL - 11

Alternative Name: Leukemia inhibitory factor (LIF) and interleukin-11 (IL-11)

Description: Leukemia inhibitory factor (LIF) and interleukin-11 (IL-11) both belong to the IL-6 family of cytokines. In mice lacking LIF, females were infertile as a result of inability of blastocysts to implant in the uterus. In mice lacking the ?-subunit of the IL-11 receptor, females were infertile as a disturbance to the decidualization process.

Target

Product Details

User: Female

Hormonal: No

Duration Type: Short-acting

Role in reproduction: Implantation

Multipurpose Preventive Technology (MPT): Yes

Status Details

Developer: Prince Henry's Institute of Medical Research, Australia

Project Phase: Discovery and Early Development

Development Stage: Target Validation

Active Development: No

Status Details:
  • Small peptide antagonists to LIF receptor have been developed and were shown to block implantation in mouse models
  • however, due to their short half-life in vivo, they had to be frequently administered.
  • A PEGlyated version has been developed but further formulation refinement is needed for additional testing.
  • Similar technology used to create the LIF receptor antagonist has been using to create an IL-11 receptor antagonists, but in vivo tests have not yet been completed.
  • The formulation of PEGlyated LIF receptor antagonist needs to be refined and proof-of-principle established in vivo.

Additional Information

References:
  • Sengupta J, Lalitkumar PG, et al. (2006) Monoclonal anti-leukemia inhibitory factor antibody inhibits blastocyst implantation in the rhesus monkey. Contraception. 74:419-425

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