MENT Implant
Alternative Name: MENT Acetate Implant, 7α-methyl-19-nortestosterone
Description: MENT is a synthetic androgen that binds with greater binding affinity than testosterone and dihydrotestosterone, the two active endogenous androgens. This higher bioactivity allows a reduced dose compared to testosterone for daily use.
Product Details
User: Male
Hormonal: Yes
Delivery Method: Subdermal
Duration Type: Long-acting
Duration: One year
Regimen: - 4 implants replaced after one year
- 4 implants replaced after one year
Dose: 1200-1600 µg (per day)
Active Pharmaceutical Ingredient (API): - 7alpha-Methyl-19-Nortestosterone
- 7alpha-Methyl-19-Nortestosterone
Inactive material: elastomer; EVA
Multipurpose Preventive Technology (MPT): No
Status Details
Developer: Population Council
Project Phase: Pre-Clinical and Clinical Development
Development Stage: Phase II
Began discovery in: 1990
Active Development: Yes
Status Details: - Four MENT Ac implants were not totally efficacious in men. MENT Ac implants in combination with DMPA injections are being investigated for synergy in efficacy to induce azoospermia.
- Four MENT Ac implants were not totally efficacious in men. MENT Ac implants in combination with DMPA injections are being investigated for synergy in efficacy to induce azoospermia.
Additional Information
References: Population Council website: http://www.popcouncil.org/research/ment-subdermal-implants-for-men
Kumar N, Crozat A, Li F, Catterall JF, Bardin CW, Sundaram K. 7alpha-methyl-19-nortestosterone, a synthetic androgen with high potency: structure-activity comparisons with other androgens. J Steroid Biochem Mol Biol. 1999 Dec 31;71(5-6):213-22. doi: 10.1016/s0960-0760(99)00143-0.
von Eckardstein S, Noe G, Brache V, Nieschlag E, Croxatto H, Alvarez F, Moo-Young A, Sivin I, Kumar N, Small M, Sundaram K. A clinical trial of 7 alpha-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for men. J Clin Endocrinol Metab. 2003 Nov;88(11):5232-9. doi: 10.1210/jc.2002-022043.
Population Council website: http://www.popcouncil.org/research/ment-subdermal-implants-for-men
Kumar N, Crozat A, Li F, Catterall JF, Bardin CW, Sundaram K. 7alpha-methyl-19-nortestosterone, a synthetic androgen with high potency: structure-activity comparisons with other androgens. J Steroid Biochem Mol Biol. 1999 Dec 31;71(5-6):213-22. doi: 10.1016/s0960-0760(99)00143-0.
von Eckardstein S, Noe G, Brache V, Nieschlag E, Croxatto H, Alvarez F, Moo-Young A, Sivin I, Kumar N, Small M, Sundaram K. A clinical trial of 7 alpha-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for men. J Clin Endocrinol Metab. 2003 Nov;88(11):5232-9. doi: 10.1210/jc.2002-022043.
Footnotes: - See also entry on MENT Gel.
- See also entry on MENT Gel.