MENT Implant

Alternative Name: MENT Acetate Implant, 7α-methyl-19-nortestosterone

Description: MENT is a synthetic androgen that binds with greater binding affinity than testosterone and dihydrotestosterone, the two active endogenous androgens. This higher bioactivity allows a reduced dose compared to testosterone for daily use.

Product Details

User: Male

Hormonal: Yes

Delivery Method: Subdermal

Duration Type: Long-acting

Duration: One year

  • 4 implants replaced after one year

Dose: 1200-1600 µg (per day)

Active Pharmaceutical Ingredient (API):
  • 7alpha-Methyl-19-Nortestosterone

Inactive material: elastomer; EVA

Multipurpose Preventive Technology (MPT): No

Status Details

Developer: Population Council

Project Phase: Pre-Clinical and Clinical Development

Development Stage: Phase II

Began discovery in: 1990

Active Development: Yes

Status Details:
  • Four MENT Ac implants were not totally efficacious in men. MENT Ac implants in combination with DMPA injections are being investigated for synergy in efficacy to induce azoospermia.

Additional Information

  • Population Council website:

  • Kumar N, Crozat A, Li F, Catterall JF, Bardin CW, Sundaram K. 7alpha-methyl-19-nortestosterone, a synthetic androgen with high potency: structure-activity comparisons with other androgens. J Steroid Biochem Mol Biol. 1999 Dec 31;71(5-6):213-22. doi: 10.1016/s0960-0760(99)00143-0.

  • von Eckardstein S, Noe G, Brache V, Nieschlag E, Croxatto H, Alvarez F, Moo-Young A, Sivin I, Kumar N, Small M, Sundaram K. A clinical trial of 7 alpha-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for men. J Clin Endocrinol Metab. 2003 Nov;88(11):5232-9. doi: 10.1210/jc.2002-022043.

  • See also entry on MENT Gel.

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