RTI-4587-073(l)

Alternative Name: l-CDB-4022

Description: RTI-4587-073(l) is the L-isomer of an indenopyridine derivative that displays strong anti-spermatogenic activity by disrupting Sertoli and Leydig cells.

Product Details

User: Male

Hormonal: No

Delivery Method: Oral

Duration Type: Short-acting

Multipurpose Preventive Technology (MPT): No

Status Details

Project Phase: Discovery and Early Development

Development Stage: Lead Optimization

Additional Information

References:
  • Pozor, M. A., Macpherson, M. L., Mcdonnell, S. M., Nollin, M., Roser, J. F., Love, C., . . . Troedsson, M. H. (2013). Indenopyride derivative RTI-4587-073(l): A candidate for male contraception in stallions. Theriogenology, 80(9), 1006-1016.

  • Pozor, M., Zambrano, G., Roser, J., Hess, R., Runyon, S., Runcan, E., . . . Kelleman, A. (2014). Acute and Chronic Effects ofa Contraceptive Compound RTI-4587-073(l) on Testicular Histology and Endocrine Function in Miniature Horse Stallions. Reproduction in Domestic Animals, 49(3), 392-402.

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