Subtilosin

Description: Subtilosin is a cyclopeptide synthesized in the ribosome by certain species of bacteria. Subtilosin destroys motility of human sperm, and has antimicrobial properties against G. vaginalis and antiviral properties against herpes simplex virus (HSV-I).

Product Details

User: Female

Hormonal: No

Delivery Method: Other

Duration Type: Pericoital

Multipurpose Preventive Technology (MPT): Yes

Status Details

Project Phase: Discovery and Early Development

Development Stage: Lead Optimization

Active Development: Unknown

Additional Information

References:
  • Noll, K.S., Sinko, P. and Chikindas, M. (2010). Elucidation of the Molecular Mechanisms of Action of the Natural Antimicrobial Peptide Subtilosin Against the Bacterial Vaginosis-associated Pathogen Gardnerella vaginalis.Probiotics and Antimicrobial Proteins, 3(1), pp.41-47.

  • Rajan, S.S., Cavera, V., Zhang, X., Singh, Y., Chikindas, M. and Sinko, P. (2014). Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis.Antimicrobial Agents and Chemotherapy, 58(5), pp.2747-2753.

  • Silkin, L., Hamza, S., Kaufman, S., Cobb, S. and Vederas, J. (2008). Spermicidal bacteriocins: Lacticin 3147 and subtilosin A.Bioorganic & Medicinal Chemistry Letters, 18(10), pp.3103-3106.

  • Sutyak, K.E., Anderson, R.A., Dover, S.E., Feathergill, K.A., Aroutcheva, A.A., Faro, S., Chikindas, M.L.(2008). Spermicidal activity of the safe natural antimicrobial peptide subtilosin. Infectious diseases in obstetrics and gynecology 2008, 540758.

  • Torres, N., Noll, K., Xu, S., Li, J., Huang, Q., Sinko, P., Wachsman, M. and Chikindas, M. (2013). Safety, Formulation and In Vitro Antiviral Activity of the Antimicrobial Peptide Subtilosin Against Herpes Simplex Virus Type 1.Probiotics and Antimicrobial Proteins, 5(1), pp.26-35.

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