Testis-expressed Gene 14 (TEX14)

Description: During gametogenesis, male germ cells form a unique structure called the intercellular bridge (IB). It is thought the IB plays a role in germ cell communication, synchronization, and chromosome dosage compensation in haploid cells. TEX14 is critical in the formation of the IB; absence of TEX14 disrupts IB formation and causes sterility.

Target

Product Details

User: Male

Hormonal: No

Role in reproduction: Spermatogenesis

Multipurpose Preventive Technology (MPT): No

Status Details

Developer: Baylor College of Medicine, NICHD

Project Phase: Discovery and Early Development

Development Stage: Target Validation

Active Development: Unknown

Status Details:
  • Target has been validated in knock-out mice models. IB were absent in TEX14-/- mice; mice were sterile.

Additional Information

References:
  • Greenbaum MP, et al. (2009) Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility. Biol Repro. 80(3): 449-57

  • Greenbaum MP, et al. (2007) Conversion of midbodies into germ cell intercellular bridges. Dev Biol. 305:389-396.

  • Greenbaum MP, et al. (2006) TEX14 is essential for intercellular bridges and fertility in male mice. Proc Natl Acad Sci USA 103: 4982-4987.

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