Testis-expressed gene 14 (TEX14)

Product Overview

Target: Male

Mode: Non-hormonal

Delivery Type: TBD

Duration Type: TBD

Description: During gametogenesis, male germ cells form a unique structured called the intercellular bridge (IB). It is thought the IB plays a role in germ cell communication, synchronization, and chromosome dosage compensation in haploid cells. TEX14 is critical in the formation of the IB; absence of TEX14 disrupts IB formation and causes sterility.

Updated date: May 30, 2018

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Status

Project Phase: Discovery

Project Stage: Target ID/Validation

Status Details:
  • Target has been validated in knock-out mice models. IB were absent in TEX14-/- mice; mice were sterile.

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