Yaso Gel

Alternative Name: PPCM Vaginal Gel

Description: PPCM is a condensation polymer made from mandelic acid and is incorporated into a consumer-pleasing gel (or film or ovule) that is inserted vaginally prior to intercourse. This novel polymer inhibits glycoprotein mediated attachment and fusion of pathogens (HSV, HIV) to target cells. PPCM also inhibits sperm function by causing premature acrosomal loss.

Product Details

User: Female

Hormonal: No

Delivery Method: Vaginal Gel, Vaginal, Other

Duration Type: Pericoital

Duration: Single use

Regimen:
  • Administer prior to intercourse

Dose: 100 mg

Active Pharmaceutical Ingredient (API):
  • poly-[1, 4-phenylene-(1-carboxy) methylene] (PPCM)

Inactive material: CMC; xanthan gum; propylene glycol; water

Multipurpose Preventive Technology (MPT): Yes

Status Details

Developer: Yaso Therapeutics, NIAID, Albert Einstein College of Medicine, University of Illinois at Chicago

Project Phase: Pre-Clinical and Clinical Development

Development Stage: Pre-clinical

Began discovery in: 2006

Active Development: Yes

Additional Information

References:
  • Yaso Therapeutics website: https://www.yasotherapeutics.com/

  • Anderson R, et al. (2006) SAMMA Induces Premature Human Acrosomal Loss by Ca2+ Signaling Dysregulation. Journal of Andrology. 27: 568-577.

  • Mesquita P, et al. (2008) Candidate Microbicide PPCM Blocks Human Immunodeficiency Virus Type 1 Infection in Cell and Tissue Cultures and Prevents Genital Herpes in a Murine Model. Journal of Virology. 6576-6584.

Footnotes:
  • PPCM was developed based on the earlier polymer, SAMMA. Several publications on SAMMA are publicly available on the Yaso Biotechnology website.

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