Yaso Gel
Alternative Name: PPCM Vaginal Gel
Description: PPCM is a condensation polymer made from mandelic acid and is incorporated into a consumer-pleasing gel (or film or ovule) that is inserted vaginally prior to intercourse. This novel polymer inhibits glycoprotein mediated attachment and fusion of pathogens (HSV, HIV) to target cells. PPCM also inhibits sperm function by causing premature acrosomal loss.
Product Details
Delivery Method: ,
Duration: Single use
Regimen:
Dose: 100 mg
Active Pharmaceutical Ingredient (API):
Inactive material: CMC; xanthan gum; propylene glycol; water
Status Details
Developer: , , ,
Began discovery in: 2006
Additional Information
References: Yaso Therapeutics website: https://www.yasotherapeutics.com/
Anderson R, et al. (2006) SAMMA Induces Premature Human Acrosomal Loss by Ca2+ Signaling Dysregulation. Journal of Andrology. 27: 568-577.
Mesquita P, et al. (2008) Candidate Microbicide PPCM Blocks Human Immunodeficiency Virus Type 1 Infection in Cell and Tissue Cultures and Prevents Genital Herpes in a Murine Model. Journal of Virology. 6576-6584.
Yaso Therapeutics website: https://www.yasotherapeutics.com/
Anderson R, et al. (2006) SAMMA Induces Premature Human Acrosomal Loss by Ca2+ Signaling Dysregulation. Journal of Andrology. 27: 568-577.
Mesquita P, et al. (2008) Candidate Microbicide PPCM Blocks Human Immunodeficiency Virus Type 1 Infection in Cell and Tissue Cultures and Prevents Genital Herpes in a Murine Model. Journal of Virology. 6576-6584.
Footnotes: - PPCM was developed based on the earlier polymer, SAMMA. Several publications on SAMMA are publicly available on the Yaso Biotechnology website.
- PPCM was developed based on the earlier polymer, SAMMA. Several publications on SAMMA are publicly available on the Yaso Biotechnology website.